Cardinals vs 49ers Prediction

Overall: venue ignored · using games through Nov 2, 2026

79%13

Our pick: 49ers, 79% to win · projected 20–33

49ers 88%

Cardinals #27 vs 49ers #13 in our rankings (network centrality).

49ers 84%

49ers by 18.8 points here, from 4 comparisons.

49ers 77%

Projected Cardinals 20, 49ers 33 from opponent-adjusted points scored and allowed.

Cardinals vs 49ers head to head this season

Against the same teams: Cardinals went 1–2, 49ers went 3–0. The edge compares average margins, as played.

Opponent	Cardinals	49ers	Edge
Seahawks	L 7–31 home, Sep 20	W 32–29 away, Oct 11	SF +27.0
Broncos	L 16–30 home, Oct 25	W 24–14 home, Oct 4	SF +24.0
Rams	W 18–16 away, Oct 18	W 27–7 neutral, Sep 10	SF +18.0