Our rankings
Lions 59%
Lions #7 vs 49ers #13 in our rankings (network centrality).
Lions vs 49ers Prediction
Overall: venue ignored · using games through Nov 2, 2026
Our pick
Our pick: 49ers, 54% to win · projected 25–29
Common opponents
Lions 77%
Lions by 18.0 points here, from 1 comparison.
Efficiency
49ers 60%
Projected Lions 25, 49ers 29 from opponent-adjusted points scored and allowed.
Lions and 49ers common opponents · 1
Against the same teams: Lions went 1–0, 49ers went 1–0. The edge compares average margins, as played.
| Opponent | Lions | 49ers | Edge |
|---|---|---|---|
 Cardinals |
W 45–21 away, Oct 11 | W 36–30 home, Sep 27 | DET +18.0 |