Our rankings
Jaguars 68%
Jaguars #1 vs 49ers #13 in our rankings (network centrality).
Jaguars vs 49ers Prediction
Played on a neutral floor · using games through Nov 2, 2026
Our pick
Our pick: Jaguars, 57% to win · projected 25–21
Common opponents
49ers 71%
49ers by 13.0 points here, from 1 comparison.
Efficiency
Jaguars 60%
Projected Jaguars 25, 49ers 21 from opponent-adjusted points scored and allowed.
Jaguars and 49ers common opponents · 1
Against the same teams: Jaguars went 0–1, 49ers went 1–0. The edge compares average margins, adjusted 2 points for home field.
| Opponent | Jaguars | 49ers | Edge |
|---|---|---|---|
 Broncos |
L 13–20 away, Sep 20 | W 24–14 home, Oct 4 | SF +13.0 |