Chargers vs 49ers Prediction

Overall: venue ignored · using games through Nov 2, 2026

79%13

Our pick: 49ers, 79% to win · projected 15–27

49ers 93%

Chargers #32 vs 49ers #13 in our rankings (network centrality).

49ers 85%

49ers by 19.8 points here, from 4 comparisons.

49ers 76%

Projected Chargers 15, 49ers 27 from opponent-adjusted points scored and allowed.

Chargers and 49ers common opponents · 4

Against the same teams: Chargers went 0–4, 49ers went 4–0. The edge compares average margins, as played.

Opponent	Chargers	49ers	Edge
Rams	L 9–24 away, Nov 1	W 27–7 neutral, Sep 10	SF +35.0
Cardinals	L 14–26 home, Sep 13	W 36–30 home, Sep 27	SF +18.0
Broncos	L 17–23 home, Oct 11	W 24–14 home, Oct 4	SF +16.0
Seahawks	L 23–30 away, Oct 4	W 32–29 away, Oct 11	SF +10.0