Our rankings
49ers 79%
Giants #21 vs 49ers #13 in our rankings (network centrality).
Giants vs 49ers Prediction
Overall: venue ignored · using games through Nov 2, 2026
Our pick
Our pick: 49ers, 72% to win · projected 19–28
Common opponents
49ers 76%
49ers by 14.0 points here, from 3 comparisons.
Efficiency
49ers 70%
Projected Giants 19, 49ers 28 from opponent-adjusted points scored and allowed.
Giants and 49ers common opponents · 3
Against the same teams: Giants went 1–1–1, 49ers went 3–0. The edge compares average margins, as played.
| Opponent | Giants | 49ers | Edge |
|---|---|---|---|
 Rams |
L 6–28 away, Sep 21 | W 27–7 neutral, Sep 10 | SF +42.0 |
 Cardinals |
W 36–24 home, Oct 4 | W 36–30 home, Sep 27 | NYG +6.0 |
 Commanders |
T 27–27 away, Oct 11 | W 23–17 home, Oct 19 | SF +6.0 |