49ers vs Cardinals Prediction

Overall: venue ignored · using games through Nov 2, 2026

21%27

Our pick: 49ers, 79% to win · projected 33–20

49ers 88%

49ers #13 vs Cardinals #27 in our rankings (network centrality).

49ers 84%

49ers by 18.8 points here, from 4 comparisons.

49ers 77%

Projected 49ers 33, Cardinals 20 from opponent-adjusted points scored and allowed.

49ers vs Cardinals head to head this season

Against the same teams: 49ers went 3–0, Cardinals went 1–2. The edge compares average margins, as played.

Opponent	49ers	Cardinals	Edge
Seahawks	W 32–29 away, Oct 11	L 7–31 home, Sep 20	SF +27.0
Broncos	W 24–14 home, Oct 4	L 16–30 home, Oct 25	SF +24.0
Rams	W 27–7 neutral, Sep 10	W 18–16 away, Oct 18	SF +18.0