Our rankings
Lions 56%
49ers #13 vs Lions #7 in our rankings (network centrality).
49ers vs Lions Prediction
Played at 49ers · using games through Nov 2, 2026
Our pick
Our pick: 49ers, 57% to win · projected 30–24
Common opponents
Lions 80%
Lions by 20.0 points here, from 1 comparison.
Efficiency
49ers 64%
Projected 49ers 30, Lions 24 from opponent-adjusted points scored and allowed.
49ers and Lions common opponents · 1
Against the same teams: 49ers went 1–0, Lions went 1–0. The edge compares average margins, adjusted 2 points for home field.
| Opponent | 49ers | Lions | Edge |
|---|---|---|---|
 Cardinals |
W 36–30 home, Sep 27 | W 45–21 away, Oct 11 | DET +22.0 |