49ers vs Chargers Prediction

Overall: venue ignored · using games through Nov 2, 2026

21%32

Our pick: 49ers, 79% to win · projected 27–15

49ers 93%

49ers #13 vs Chargers #32 in our rankings (network centrality).

49ers 85%

49ers by 19.8 points here, from 4 comparisons.

49ers 76%

Projected 49ers 27, Chargers 15 from opponent-adjusted points scored and allowed.

49ers and Chargers common opponents · 4

Against the same teams: 49ers went 4–0, Chargers went 0–4. The edge compares average margins, as played.

Opponent	49ers	Chargers	Edge
Rams	W 27–7 neutral, Sep 10	L 9–24 away, Nov 1	SF +35.0
Cardinals	W 36–30 home, Sep 27	L 14–26 home, Sep 13	SF +18.0
Broncos	W 24–14 home, Oct 4	L 17–23 home, Oct 11	SF +16.0
Seahawks	W 32–29 away, Oct 11	L 23–30 away, Oct 4	SF +10.0