Our rankings
49ers 79%
49ers #13 vs Giants #21 in our rankings (network centrality).
49ers vs Giants Prediction
Overall: venue ignored · using games through Nov 2, 2026
Our pick
Our pick: 49ers, 72% to win · projected 28–19
Common opponents
49ers 76%
49ers by 14.0 points here, from 3 comparisons.
Efficiency
49ers 70%
Projected 49ers 28, Giants 19 from opponent-adjusted points scored and allowed.
49ers and Giants common opponents · 3
Against the same teams: 49ers went 3–0, Giants went 1–1–1. The edge compares average margins, as played.
| Opponent | 49ers | Giants | Edge |
|---|---|---|---|
 Rams |
W 27–7 neutral, Sep 10 | L 6–28 away, Sep 21 | SF +42.0 |
 Cardinals |
W 36–30 home, Sep 27 | W 36–24 home, Oct 4 | NYG +6.0 |
 Commanders |
W 23–17 home, Oct 19 | T 27–27 away, Oct 11 | SF +6.0 |